The next industrial revolution is inspired and driven by the emergence of a new generation of engineered systems: Cyber-Physical Systems (CPS). Such systems use computation and communication deeply embedded in and interacting with physical processes to transform the behavior and capabilities of physical systems. CPS is not about adding computing and communication equipment to conventional products where the computing and physical sides maintain their separate identities. In CPS, functionalities are emerging from the networked interaction between computing and physical systems. The range of CPS products spans from the minuscule (e.g. pacemakers) to the large-scale (e.g. cars, airplanes) and include systems that our life depends on (e.g. the national power-grid). Complexity of their design demands new scientific foundation - a new CPS Systems Science - that requires the synthesis of knowledge across many science and engineering disciplines including computing, networking, control, security, human interaction, learning theory, as well as mechanical, chemical, biomedical, and other engineering disciplines. The objective of the National Science Foundation established CPS Virtual Organization (CPS-VO) is to actively support the formation of a multidisciplinary community and to facilitate broadly based collaboration on CPS.