This project investigates new reinforcement learning (RL) approaches for cyber-physical autonomy to bridge the gap between current intelligent systems and human-level intelligence. The nature of many cyber-physical systems (CPS) is distributed, heterogeneous, and high-dimensional, making the hand-coded functions and task-specific information hard to design in the learning scheme. Large amount of training data is often required for achieving the desired performance, however this limits the generalization to other tasks. Hence, this project is to explore the new RL strategies to enable CPS with the capabilities of autonomous learning and generalization to rapidly adapt in unknown situations that were not assumed in the design phase. The results are expected to transform how agents interact in high-dimensional and heterogeneous environment, and therefore could potentially provide in-depth findings for exploring creativity in frontier Artificial Intelligence techniques.