There is no question that indoor environments are often uncomfortable or unhealthy for occupants. This is an even more critical issue in healthcare facilities, where patients may experience the stressful effects of poor thermal, luminous, and acoustic environments more acutely. With complementary expertise from engineering and psychology, the proposed research is focused on creating a human-on-the-loop, responsive indoor environmental system with the potential to offer better quality of care in hospitals. The outputs of this project will have profound societal impacts on the wellbeing of both healthy individuals and on recovering sick individuals. Research outcomes will enable real time human-built environment interaction to minimize stress and optimize performance in any built environment, and ultimately lead towards economic benefits achieved through wellness and higher productivity. Improved indoor environmental quality in hospital settings will improve patient healing, which is an important societal benefit. Similar strategies can be used for educational facilities, and office buildings. This research encourages Broadening Participation through inclusion of individuals from underrepresented groups (female and Latinx Co-PIs), female and minority students, and a minority serving lead institution from an EPSCoR state. Results will be disseminated broadly through scientific publications and seminars, and K-12 outreach, including STEM competitions, and summer programs.