Microbial pathogen transmission in buildings is an urgent public health concern. The pandemic of coronavirus disease 2019 (COVID-19) adds to the urgency of developing effective means to reduce pathogen transmission in public buildings with minimal disruptions in building functions. With the ultimate goal to develop healthy buildings that minimize risks of infectious diseases, this project will develop smart control strategies for buildings and assistive robots to mitigate pathogen transmission and occupant exposure. New techniques will be developed to monitor and predict pathogen spreading, automate building ventilation, enable intelligent recognition of contaminated objects, and perform precision disinfection to reduce pathogen transmission through air circulation and surface contacts. Findings from this project will also guide occupants and facility managers to develop and implement effective behavioral interventions and hygiene practices. If successful, this research will revolutionize the control of built environments to enable protection against infectious diseases, which will have vast public health and economic benefits to the nation. This project will also create new and unique opportunities to stimulate the academic interests of students and support the development of next-generation workforce adequately equipped with interdisciplinary computing and engineering skills needed to address challenges facing the nation.