Origami-inspired structures that fold flat sheets along creases with designed patterns to create transformable structures have been widely applied in science and engineering, especially in space operations, e.g., for deployment of folded solar panels equipped on launched satellites. Although the deformation process plays an essential role in transitions between the origami states, few studies focus on the control and actuation of the origami folding mechanism toward high autonomy of the deformation process. This project aims to develop an autonomous origami-inspired transformable system to enable high-performance deformation maneuvering in space operations requiring frequent and/or time-responsive shape changes. The integrative research incorporating theory, analysis, algorithm development, and experimental verification will contribute to a theoretical and experimental platform to advance the autonomy of origami system operations in challenging environments. The research products will have significant impacts on the proliferated satellite marketplace where low mass, small volume, and adaptable structures/subsystems of space vehicles are in demand. Going beyond the applications in space missions, origami-inspired transformable systems have much broader applications in science and engineering. Moreover, the collaboration of experts in both cyber and physical areas promotes the creation of interdisciplinary products that bridge different disciplines.