In this ongoing study, we are exploring the suitability of a novel technique based on the estimation of muscle synergies to control a hand prosthesis. The objective of the study is to predict thirteen distinct hand grasp movements using EMG data. The method relies on projecting the EMG data using a basis derived via analysis of the muscle synergies. Five healthy subjects performed a set of thirteen distinct hand grasp movements while sEMG data from seven muscles have been recorded.