Human-driven vehicles (HDVs) and automated vehicles (AVs) of all levels (Level 1-5, AVs1-5) may share the highways in the long and foreseeable future. The increasing vehicle autonomy heterogeneity and diversity may jeopardize the safe and harmonious interaction among such vehicles with mixed autonomy on highways and pose a threat to the safety of all vehicles. This may exacerbate an already growing and alarming national concern on traffic safety. This project aims to advance the state of the art in the Cyber-Physical Systems (CPS) research areas of Autonomy, Safety, and Transportation by ushering in a new CPS paradigm of harmonious and safe integration of highway vehicles with heterogeneous, varying, and mixed human / machine autonomy. Through collaborative research, the project may create new methods and tools to enhance the highway driving safety of heterogeneous vehicles. The outcomes of this work may also be extended to advance other CPS in manufacturing, warehousing, and healthcare applications where interaction among humans and heterogeneous autonomous robots is pervasive and safe coordination among them is critical.