Aquaculture, i.e., farming in an aquatic environment, plays an ever-growing role in food security in the US and worldwide. Since 2014 globally, more seafood consumed was farm-raised than wild-caught. Regrettably, aquaculture in the U.S. needs to catch up with the rest of the world, hindered by the high cost of resource-intensive operations. The labor shortage experienced in the industry exacerbates the problem.To revitalize the growth of the U.S. aquaculture industry, the proposed three-year Medium project - Intelligent Resource Efficient Pond Aquaculture (IREPA), aims to achieve transformative improvements in the productivity and sustainability in key pond aquaculture operations, namely, water quality management (i.e., monitoring and aeration), and feeding. The core concept of IREPA is to transform farm operations from the traditional reactive mode to proactive feedforward controlled processes underpinned by Cyber-Physical Systems (CPS), which include an AI-driven farm operation and control and heterogeneous robotic systems connected through a high-speed low-latency network infrastructure to seamlessly collaborate with and assist the human operators.