In pursuit of the long-term goal of enabling interpretable “white-box” autonomy in healthcare, the goal of this project is to investigate physiological modeling, coordinated and resilient multivariable closed-loop control, and regulatory science methodologies for white-box autonomy, as well as to illustrate its application to an important critical care scenario of circulatory resuscitation.  The idea of introducing autonomy to the healthcare domain is not new.  However, prior autonomy capabilities have not been suitably mature for real-world critical care, due to the limitations a