During the last decade, we have witnessed a rapid penetration of autonomous systems technology into aerial, road, underwater, and sea vehicles. The autonomy assumed by these vehicles holds the potential to increase performance significantly, for instance, by reducing delays and increasing capacity, while enhancing safety, in a number of transportation systems. However, to exploit the full potential of these autonomy-enabled transportation systems, we must rethink transportation networks and control algorithms that coordinate autonomous vehicles operating on such networks. This project focuses on the design and operation of autonomy-enabled transportation networks that provide provable guarantees on achieving high performance and maintaining safety at all times. The foundational problems arising in this domain involve taking into account the physics governing the vehicles in order to coordinate them using cyber means. This research effort aims to advance the science of cyber-physical systems by following a unique and radical approach, drawing inspiration and techniques from non-equilibrium statistical mechanics and self-organizing systems, and blending this inspiration with the foundational tools of queueing theory, control theory, and optimization. This approach may allow orders of magnitude improvement in the servicing capabilities of various transportation networks for moving goods or people. The applications include the automation of warehouses, factory floors, sea ports, aircraft carrier decks, transportation networks involving driverless cars, drone-enabled delivery networks, air traffic management, and military logistics networks. The project also aims to start a new wave of classes and tutorials that will create trained engineers and a research community in the area of safe and efficient transportation networks enabled by autonomous cyber-physical systems.

Inadequate system understanding and inadequate situational awareness have caused large-scale power outages in the past. With the increased reliance on variable energy supply sources, system understanding and situational awareness of a complex energy system become more challenging. This project leverages the power of big data analytics to directly improve system understanding and situational awareness. The research provides the methodology for detecting anomalous events in real-time, and therefore allow control centers to take appropriate control actions before minor events develop into major blackouts. The significance for the society and for the power industry is profound. Energy providers will be able to prevent large-scale power outages and reduce revenue losses, and customers will benefit from reliable energy delivery with service guarantees. Students, including women and underrepresented groups, will be trained for the future workforce in this area. The project includes four major thrusts: 1) real-time anomaly detection from measurement data; 2) real-time event diagnosis and interpretation of changes in the state of the network; 3) real-time optimal control of the power grid; 4) scientific foundations underpinning cyber-physical systems. The major outcome of this project is practical solutions to event or fault detection and diagnosis in the power grid, as well as prediction and prevention of large-scale power outages.

Laboratory-on-a-chip (LoC) technology is poised to improve global health through development of low-cost, automated point-of-care testing devices. In countries with few healthcare resources, clinics often have drugs to treat an illness, but lack diagnostic tools to identify patients who need them. To enable low-cost diagnostics with minimal laboratory support, this project will investigate domain-specific LoC programming language and compiler design in conjunction with device fabrication technologies (process flows, sensor integration, etc.). The project will culminate by building a working LoC that controls fluid motion through electronic signals supplied by a host PC; a forensic toxicology immunoassay will be programmed in software and executed on the device. This experiment will demonstrate benefits of programmable LoC technology including miniaturization (reduced reagent consumption), automation (reduced costs and uncertainties associated with human interaction), and general-purpose software-programmability (the device can execute a wide variety of biochemical reactions, all specified in software). Information necessary to reproduce the device, along with all software artifacts developed through this research effort, will be publicly disseminated. This will promote widespread usage of software-programmable LoC technology among researchers in the biological sciences, along with public and industrial sectors including healthcare and public health, biotechnology, water supply management, environmental toxicity monitoring, and many others. This project designs and implements a software-programmable cyber-physical laboratory-on-a-chip (LoC) that can execute a wide variety of biological protocols. By integrating sensors during fabrication, the LoC obtains the capability to send feedback in real-time to the PC controller, which can then make intelligent decisions regarding which biological operations to execute next. To bring this innovative and transformative platform to fruition, the project tackles several formidable research challenges: (1) cyber-physical LoC programming models and compiler design; (2) LoC fabrication, including process flows and cyber-physical sensor integration; and (3) LoC applications that rely on cyber-physical sensory feedback and real-time decision-making. By constructing a working prototype LoC, and programming a representative feedback-driven forensic toxicology immunoassay, the project demonstrates that the proposed system can automatically execute biochemical reactions that require a closed feedback loop. Expected broader impacts of the proposed work include reduced cost and increased reliability of clinical diagnostics, engagement with U.S. companies that use LoC technology, training of graduate and undergraduate students, increased engagement and retention efforts targeting women and underrepresented minorities, student-facilitated peer-instruction at UC Riverside, a summer residential program for underrepresented minority high-school students at the University of Tennessee, collaborations with researchers at the Oak Ridge National Laboratory, and creation, presentation, and dissemination of tutorial materials to promote the adoption and use of software-programmable LoCs among the wider scientific community.