Assistive machines - like powered wheelchairs, myoelectric prostheses and robotic arms - promote independence and ability in those with severe motor impairments. As the state- of-the-art in these assistive Cyber-Physical Systems (CPSs) advances, more dexterous and capable machines hold the promise to revolutionize ways in which those with motor impairments can interact within society and with their loved ones, and to care for themselves with independence. However, as these machines become more capable, they often also become more complex. Which raises the question: how to control this added complexity? A new paradigm is proposed for controlling complex assistive Cyber-Physical Systems (CPSs), like robotic arms mounted on wheelchairs, via simple low-dimensional control interfaces that are accessible to persons with severe motor impairments, like 2-D joysticks or 1-D Sip-N-Puff interfaces. Traditional interfaces cover only a portion of the control space, and during teleoperation it is necessary to switch between different control modes to access the full control space. Robotics automation may be leveraged to anticipate when to switch between different control modes. This approach is a departure from the majority of control sharing approaches within assistive domains, which either partition the control space and allocate different portions to the robot and human, or augment the human's control signals to bridge the dimensionality gap. How to best share control within assistive domains remains an open question, and an appealing characteristic of this approach is that the user is kept maximally in control since their signals are not altered or augmented. The public health impact is significant, by increasing the independence of those with severe motor impairments and/or paralysis. Multiple efforts will facilitate large-scale deployment of our results, including a collaboration with Kinova, a manufacturer of assistive robotic arms, and a partnership with Rehabilitation Institute of Chicago. The proposal introduces a formalism for assistive mode-switching that is grounded in hybrid dynamical systems theory, and aims to ease the burden of teleoperating high-dimensional assistive robots. By modeling this CPS as a hybrid dynamical system, assistance can be modeled as optimization over a desired cost function. The system's uncertainty over the user's goals can be modeled via a Partially Observable Markov Decision Processes. This model provides the natural scaffolding for learning user preferences. Through user studies, this project aims to address the following research questions: (Q1) Expense: How expensive is mode-switching? (Q2) Customization Need: Do we need to learn mode-switching from specific users? (Q3) Learning Assistance: How can we learn mode-switching paradigms from a user? (Q4) Goal Uncertainty: How should the assistance act under goal uncertainty? How will users respond? The proposal leverages the teams shared expertise in manipulation, algorithm development, and deploying real-world robotic systems. The proposal also leverages the teams complementary strengths on deploying advanced manipulation platforms, robotic motion planning and manipulation, and human-robot comanipulation, and on robot learning from human demonstration, control policy adaptation, and human rehabilitation. The proposed work targets the easier operation of robotic arms by severely paralyzed users. The need to control many degrees of freedom (DoF) gives rise to mode-switching during teleoperation. The switching itself can be cumbersome even with 2- and 3-axis joysticks, and becomes prohibitively so with more limited (1-D) interfaces. Easing the operation of switching not only lowers this burden on those already able to operate robotic arms, but may open use to populations to whom assistive robotic arms are currently inaccessible. This work is clearly synergistic: at the intersection of robotic manipulation, human rehabilitation, control theory, machine learning, human-robot interaction and clinical studies. The project addresses the science of CPS by developing new models of the interaction dynamics between the system and the user, the technology of CPS by developing new interfaces and interaction modalities with strong theoretical foundations, and the engineering of CPS by deploying our algorithms on real robot hardware and extensive studies with able-bodied and users with sprinal cord injuries.

The timely and accurate in-service identification of faults in mechanical structures, such as airplanes, can play a vitally important role in avoiding catastrophes. One major challenge, however, is that the sensing system relies on high frequency signals, the coordination of which is difficult to achieve throughout a large structure. To tackle this fundamental issue, the research team will take advantage of 3D printing technology to fabricate integrated sensor-structure components. Specifically, the team plans to innovate a novel printing scheme that can embed piezoelectric transducers (namely, sensor/actuator coupled elements) into layered composites. As the transducers are densely distributed throughout the entire structure, they function like a nerve system embedded into the structure. Such a sensor nerve system, when combined with new control and command systems and advanced data and signal processing capability, can fully unleash the latest computing power to pinpoint the fault location. The new framework of utilizing emerging additive manufacturing technology to produce a structural system with integrated, densely distributed active sensing elements will potentially lead to paradigm-shifting progress in structural self-diagnosis. This advancement may allow the acquisition of high-quality, active interrogation data throughout the entire structure, which can then be used to facilitate highly accurate and robust decision-making. It will lead to intellectual contributions including: 1) development of a new sensing modality with mechanical-electrical dual-field adaptivity, that yields rich and high-quality data throughout the structure; 2) design of an additive manufacturing scheme that inserts piezoelectric micro transducer arrays throughout the structure to enable active interrogation; and 3) formulation of new data analytics and inverse analysis that can accurately identify the fault location/severity and guide the fine-tuning of the sensor system.

Infrastructure networks are the foundation of the modern world. Their continued reliable and efficient function without exhausting finite natural resources is critical to the security, continued growth and technological advancement of the United States. Currently these systems are in a state of rapid flux due to a collision of trends such as growing populations, expanding integration of information technology, and increasing motivation to adopt sustainable practices. These trends beget both exciting potential benefits and dangerous challenges. Added sensing, communication, and computational capabilities hold the promise of increased reliability, efficiency and sustainability from "smart" infrastructure systems. At the same time, new technologies such as renewable energy resources in power systems, autonomous vehicles, and software defined communication networks, are testing the limits of current operational and market policies. The rapidly changing suite of system components can cause new, unforeseen interactions that can lead to instability, performance deterioration, or catastrophic failures. Achieving the full benefits of these systems will require a shift from the existing focus on approaches that analyze each aspect of interest in isolation, to a more holistic view that encompasses all of the relevant factors such as stability, robustness, performance and efficiency, and takes into account the presence of human participants. This project provides a research roadmap to construct analysis, design and control tools that ensure the seamless integration of computational algorithms, physical components and human interactions in next generation infrastructure systems. Although there has been a great deal of research on stability questions in large scale distributed systems, there has been little effort directed toward questions of performance, robustness and efficiency in these systems, especially those with heterogeneous components and human participants. This research employs coupled oscillator systems as a common modeling framework to (i) characterize stability and performance of infrastructure systems, and (ii) develop distributed controllers that guarantee performance, efficiency and robustness by isolating disturbances and optimizing performance objectives. Practical solutions require that the theory be tightly integrated with the economic mechanisms necessary to incentivize users to enhance system stability, efficiency and reliability; therefore the work will also include the design of economic controls. In order to ground the mathematical foundations, theory and algorithms described above, the results will be applied to three target infrastructure networks where coupled oscillator models have played a foundational role in design and control: power, communication, and transportation systems. This approach allows the development of cross-cutting, fundamental principles that can be applied across problem specific boundaries and ensures that the research makes an impact on these specific infrastructure networks. This project will also incorporate concepts into existing undergraduate and graduate courses.

Infrastructure networks are the foundation of the modern world. Their continued reliable and efficient function without exhausting finite natural resources is critical to the security, continued growth and technological advancement of the United States. Currently these systems are in a state of rapid flux due to a collision of trends such as growing populations, expanding integration of information technology, and increasing motivation to adopt sustainable practices. These trends beget both exciting potential benefits and dangerous challenges. Added sensing, communication, and computational capabilities hold the promise of increased reliability, efficiency and sustainability from "smart" infrastructure systems. At the same time, new technologies such as renewable energy resources in power systems, autonomous vehicles, and software defined communication networks, are testing the limits of current operational and market policies. The rapidly changing suite of system components can cause new, unforeseen interactions that can lead to instability, performance deterioration, or catastrophic failures. Achieving the full benefits of these systems will require a shift from the existing focus on approaches that analyze each aspect of interest in isolation, to a more holistic view that encompasses all of the relevant factors such as stability, robustness, performance and efficiency, and takes into account the presence of human participants. This project provides a research roadmap to construct analysis, design and control tools that ensure the seamless integration of computational algorithms, physical components and human interactions in next generation infrastructure systems. Although there has been a great deal of research on stability questions in large scale distributed systems, there has been little effort directed toward questions of performance, robustness and efficiency in these systems, especially those with heterogeneous components and human participants. This research employs coupled oscillator systems as a common modeling framework to (i) characterize stability and performance of infrastructure systems, and (ii) develop distributed controllers that guarantee performance, efficiency and robustness by isolating disturbances and optimizing performance objectives. Practical solutions require that the theory be tightly integrated with the economic mechanisms necessary to incentivize users to enhance system stability, efficiency and reliability; therefore the work will also include the design of economic controls. In order to ground the mathematical foundations, theory and algorithms described above, the results will be applied to three target infrastructure networks where coupled oscillator models have played a foundational role in design and control: power, communication, and transportation systems. This approach allows the development of cross-cutting, fundamental principles that can be applied across problem specific boundaries and ensures that the research makes an impact on these specific infrastructure networks. This project will also incorporate concepts into existing undergraduate and graduate courses.

Epilepsy is one of the most common neurological disorders, affecting between 0.4% and 1% of the world's population. While seizures can be controlled in approximately two thirds of newly diagnosed patients through the use of one or more antiepileptic drugs (AEDs), the remainder experience seizures even on multiple medications. The primary impacts of the chronic condition of epilepsy on a patient are a lower quality of life, loss of productivity, comorbidities, and increased risk of death. Epilepsy is an intermittent brain disorder, and in localization-related epilepsy, which is the most common form of epilepsy, one or a few discrete brain areas (the seizure focus or seizure foci) are believed to be responsible for seizure initiation. More recent approaches with implantable electrical stimulation seizure control devices hold value as a therapeutic option for the control of seizures. These devices, directly or indirectly, target the seizure focus and seek to control its expression. In this project we will build a multichannel brain implantable device based on emerging cyber physical system (CPS) principles. This brain implantable CPS device will incorporate key design features to make the device dependable, scalable, composable, certifiable, and interoperable. The device will operate over the life of an animal, or a patient, and continuously record brain activity and stimulate the brain when seizure related activity is detected to abort an impending seizure. Episodic brain disorders such as epilepsy have a considerable impact on a patient's productivity and quality of life and may be life-threatening when seizures cannot be controlled with medications. The goal of this project is to create a second generation brain-implantable sensing and stimulating device (BISSD) based on emerging CPS principles and practice. The development of a BISSD as a exemplifies several defining aspects that inform and illustrate core CPS principles. First, to meet the important challenge of regulatory approval a composable, scalable and certifiable framework that supports testing in multiple species is proposed. Second, a BISSD must be wholly integrated with the patient and fully cognizant at every instant of brain state, including dynamic changes in both the normal and abnormal expression of brain physiology and therapeutic intervention. Thus, this project seeks a tight conjunction of the cyber solution that must monitor itself and monitor and stimulate the brain using implanted, adaptable, distributed, and networked electrodes, and the physical system which in this case is the intermittently failing human brain. Third, a BISSD must function for an extensive period of time, up to the life of the patient, because each surgery to place and retrieve a BISSD carries an attendant risk. This requirement necessitates a dependable solution, which this project seeks to reliably achieve through both an understanding of the brain's foreign body response and a unique hierarchical fault-tolerant design. Fourth, an advanced salient approaches to acquire, compress, and analyze sensor signals to achieve real-time monitoring and control of seizures is employed. This project should yield a powerful, scalable CPS framework for robust fault-tolerant implantable medical devices with real-time processing that can grow with advances in sensors, sensing modalities, time-series analysis, real-time computation, control, materials, power and knowledge of underlying biology. The USA has a competitive advantage in the control of seizures in medically refractory epilepsy. In the modern era, epilepsy surgery evolved in the USA in the 1970s and spread from here to other parts of the world. Similarly, the USA enjoys a competitive advantage in BISSDs, and success in this effort will enable the USA to build on and maintain this advantage. In addition to epilepsy, advances made here can be expected to benefit the treatment of other neurological and psychiatric brain disorders.

The timely and accurate in-service identification of faults in mechanical structures, such as airplanes, can play a vitally important role in avoiding catastrophes. One major challenge, however, is that the sensing system relies on high frequency signals, the coordination of which is difficult to achieve throughout a large structure. To tackle this fundamental issue, the research team will take advantage of 3D printing technology to fabricate integrated sensor-structure components. Specifically, the team plans to innovate a novel printing scheme that can embed piezoelectric transducers (namely, sensor/actuator coupled elements) into layered composites. As the transducers are densely distributed throughout the entire structure, they function like a nerve system embedded into the structure. Such a sensor nerve system, when combined with new control and command systems and advanced data and signal processing capability, can fully unleash the latest computing power to pinpoint the fault location. The new framework of utilizing emerging additive manufacturing technology to produce a structural system with integrated, densely distributed active sensing elements will potentially lead to paradigm-shifting progress in structural self-diagnosis. This advancement may allow the acquisition of high-quality, active interrogation data throughout the entire structure, which can then be used to facilitate highly accurate and robust decision-making. It will lead to intellectual contributions including: 1) development of a new sensing modality with mechanical-electrical dual-field adaptivity, that yields rich and high-quality data throughout the structure; 2) design of an additive manufacturing scheme that inserts piezoelectric micro transducer arrays throughout the structure to enable active interrogation; and 3) formulation of new data analytics and inverse analysis that can accurately identify the fault location/severity and guide the fine-tuning of the sensor system.

Parking can take up a significant amount of the trip costs (time and money) in urban travel. As such, it can considerably influence travelers' choices of modes, locations, and time of travel. The advent of smart sensors, wireless communications, social media and big data analytics offers a unique opportunity to tap parking's influence on travel to make the transportation system more efficient, cleaner, and more resilient. A cyber-physical social system for parking is proposed to realize parking's potential in achieving the above goals. This cyber-physical system consists of smart parking sensors, a parking and traffic data repository, parking management systems, and dynamic traffic flow control. If successful, the results of the investigation will create a new paradigm for managing parking to reduce traffic congestion, emissions and fuel consumption and to enhance system resilience. These results will be disseminated broadly through publications, workshops and seminars. The research will provide interdisciplinary training to both graduate and undergraduate students. The results of this research also fills a void in our graduate transportation curriculum in which parking management gets little coverage. The investigators will organize an online short training course in Coursera and National Highway Institute to bring results to a broader audience. The investigators will also collaborate with Carnegie Museum of Natural History to develop an online digital map and related educational programs, which will be presented in the museum galleries during public events. Technically, new theories, algorithms and systems for efficient management of transportation infrastructure through parking will be developed in this research, leveraging cutting-edge sensing technology, communication technology, big data analytics and feedback control. The research probes massive individualized and infrastructure based traffic and parking data to gain a deeper understanding of travel and parking behavior, and develops a novel reservoir-based network flow model that lays the foundation for modeling the complex interactions between parking and traffic flow in large-scale transportation networks. The theory will be investigated at different levels of granularity to reveal how parking information and pricing mechanisms affect network flow in a competitive market of private and public parking. In addition, this research proposes closed-loop control mechanisms to enhance mobility and sustainability of urban networks. Prices, access and information of publicly owned on-street and off-street parking are dynamically controlled to: a) change day-to-day behavior of all commuters through day-to-day travel experience and/or online information systems; b) change travel behavior of a fraction of adaptive travelers on the fly who are aware of time-of-day parking information and comply to the recommendations; and c) influence the market prices of privately owned parking areas through a competitive parking market.

Children affected by neurological conditions (e.g., Cerebral Palsy, Muscular Atrophy, Spina Bifida and Severe head trauma) often develop significant disabilities including impaired motor control. In many cases, walking becomes a non-functional and exhausting skill that demands the use of the aids or the substitution of function, such as wheelchair. This usually cause these children not to acquire locomotion skills, and consequently to lose their independence. However, it is well understood that bipedal locomotion, an essential human characteristic, ensures the best physiological motor pattern acquisition. For this reason, in children with neurological and neuromuscular diseases, independent walking is a significant rehabilitation goal that must be pursued in a specific temporal window due to the plasticity of central nervous system. In other words, children with neurological conditions have a small window of time to acquire locomotion skills through assisted walking rehearsals. The objective of this research work is to create and experimentally validate a set of technologies that form the framework for the development of adaptive, self-balancing, and modular exoskeleton robotics systems for children with neurological disorders. It is our belief that the exoskeleton (and its associated infrastructure) resulting from this research will offer an effective tool to promote locomotion skill acquisition, and in general health, during a critical period in the early life of children with neurological conditions. This research proposal develops a data-driven human-machine modeling specific to physiological conditions. This creates regression models that predict the user behavior without explicit modeling the complex human musculoskeletal dynamics and motor control mechanism. Additionally this research project formulates a safe adaptive control problem as a model predictive control (MPC) problem. In this method, an optimal input sequence is computed by solving a constrained finite-time optimal control problem where exoskeleton intrusion (input from exoskeleton) is minimized to maximize the user's intent to promote learning. This project further develops a novel approach for stabilizing and preventing fall of the exoskeleton and the child as a whole. This method allows a child wearing an exoskeleton to learn locomotion skills described above with less likelihood of falls. This research project furthermore evaluates the developed technologies in terms of efficiency and efficacy and creates a novel fun game using exoskeleton for children to promote locomotion skills.