The objective of this research is to develop new principles and techniques for adaptive operation in highly dynamic physical environments, using miniaturized, energy-constrained devices. The approach is to use holistic cross-layer solutions that simultaneously address all aspects of the system, from low-level hardware design to higher-level communication and data fusion algorithms to top-level applications. In particular, this work focuses on body area sensor networks as emerging cyber-physical systems. The intellectual merit includes producing new principles regarding how cyber systems must be designed in order to continually adapt and respond to rapidly changing physical environments, sensed data, and application contexts in an energy-efficient manner. New cross-layer technologies will be created that use a holistic bottom-up and top-down design -- from silicon to user and back again. A novel system-on-a-chip hardware platform will be designed and fabricated using three cutting-edge technologies to reduce the cost of communication and computation by several orders of magnitude. The broad impact of this project will enable the wide range of applications and societal benefits promised by body area networks, including improving the quality and reducing the costs of healthcare. The technology will have broad implications for any cyber physical system that uses energy constrained wireless devices. A new seminar series will bring together experts from many fields (including domain experts, such as physicians and healthcare professionals). The key aspects of this work that deal with healthcare have the potential to attract women and minorities to the computer field.

The objective of this research is to establish a new development paradigm that enables the effective design, implementation, and certification of medical device cyber-physical systems. The approach is to pursue the following research directions: 1) to support medical device interconnectivity and interoperability with network-enabled control; 2) to apply coordination between medical devices to support emerging clinical scenarios; 3) to ?close the loop? and enable feedback about the condition of the patient to the devices delivering therapy; and 4) to assure safety and effectiveness of interoperating medical devices. The intellectual merits of the project are 1) foundations for rigorous development, which include formalization of clinical scenarios, operational procedures, and architectures of medical device systems, as well as patient and caregiver modeling; 2) high-confidence software development for medical device systems that includes the safe and effective composition of clinical scenarios and devices into a dynamically assembled system; 3) validation and certification of medical device cyber-physical systems; and 4) education of the next-generation of medical device system developers who must be literate in both computational and physical aspects of devices. The broader impacts of the project will be achieved in three ways. Novel design methods and certification techniques will significantly improve patient safety. The introduction of closed-loop scenarios into clinical practice will reduce the burden that caregivers are currently facing and will have the potential of reducing the overall costs of health care. Finally, the educational efforts and outreach activities will increase awareness of careers in the area of medical device systems and help attract women and under-represented minorities to the field.

Tens of thousands of the nation?s bridges are structurally deficient. This project proposes to design a self sustaining, wireless structural monitoring system. The novel low-power Flash FPGA-based hardware platform and the corresponding software architecture offer a radically new approach to CPS design. A soft multi-core platform where software modules that run in parallel will be guaranteed to have dedicated single-threaded soft processor cores enables flexible power management by running only the necessary cores at any given time at the slowest clock rate mandated by the observed/controlled physical phenomena. As bridges tend to vibrate due to wind and dynamic load conditions, we are developing a novel vibration-based energy harvesting device that is capable of automatically adjusting its resonant response in order to capture much more energy than the current techniques can. Moreover, the PIs are developing structural health assessment techniques involving quantitative analysis of signals to determine crack type, location and size. The technology will indicate structural problems before they become critical potentially saving human lives and averting late and extensive repairs. The impact of the vibration harvesting technique and the soft multi-core architecture will go beyond structural monitoring. A separate soft core dedicated to each software component that interacts with the physical world will make CPS more responsive while saving power at the same time. The education plan focuses on outreach toward underrepresented minorities by recruiting such undergraduates to participate in the research. To facilitate the dissemination of our results, all hardware designs and software developed under this project will be open source.