Autonomous navigation in unknown and dynamic environments has been a major challenge for synthetic mobile robotic agents. On the other hand, insects can easily solve such complex navigational problems and demonstrate remarkably stable and optimized locomotion skills in almost any environment. This project aims to develop a mobile sensor network where insects are used as mobile biological-robotic (biobotic) nodes. Insects, in fact, build a "natural" sensor network through the use of their biological sensing organs and release of chemical, mechanical and optical cues to communicate the information to the rest of the group. In the scope of this project, a novel cyber-physical communication network will be established among the individual insect in addition to the aforementioned natural one. For this, insects will be equipped with synthetic electronic sensors to sense additional cues, neuromuscular stimulation systems to direct the control of the insect and microcontrollers with radios to establish an RF link between the insects. This novel network will enable operation of insect biobots in complicated and uncertain dynamic environments for applications such as environmental sensing and search-and-rescue operations after natural disasters. The unique interdisciplinary nature of this project will help engineers to reach to younger generations and train them to be able to look at engineering problems from a cyberphysical systems point of view. Planned activities include development of lab modules and demos by undergraduate and graduate students to teach K-12 students and their teachers through our on-going collaborations with educational partners. These demos will also be instrumental during nation level efforts to promote graduate education to underrepresented minority students.

Growing demands on our civil infrastructure have heightened the need for smart structural components and systems whose behavior and performance can be controlled under a variety of loading scenarios such as high winds and earthquakes. However, due to the sheer size, scale and cost of most civil engineering structures, design and testing of such smart structures needs to be conducted using a hybrid cyber-physical approach where the infrastructure system in question, for example a bridge, is studied by coupling a small number of physical components with a numerical model of the rest of the structure. Undoubtedly, the success of such a hybrid approach, especially for dynamic real-time applications, hinges on effective integration of the cyber and physical components of the system. This project provides the essential building blocks and a computational integration platform to enable real-time hybrid testing of civil engineering structures. Design and development of physical components, multi-level numerical models, and real-time control algorithms will be conducted at Purdue University. Washington University will provide an adaptive, configurable concurrency platform and communication mechanisms that meet the strict scheduling constraints of real-time cyber-physical systems. The two institutions will collaboratively design a prototype system and conduct extensive testing to validate the integration of the various components and evaluate system performance. Specifications, software, benchmarks, and data developed during the course of this project will be made freely available to the cyber-physical research community. In addition to directly advancing the state-of-the-art in real-time hybrid testing, this research will also impact the areas of avionics, automotive design, smart grids for distributed power transmission and similar applications in other domains.

Growing demands on our civil infrastructure have heightened the need for smart structural components and systems whose behavior and performance can be controlled under a variety of loading scenarios such as high winds and earthquakes. However, due to the sheer size, scale and cost of most civil engineering structures, design and testing of such smart structures needs to be conducted using a hybrid cyber-physical approach where the infrastructure system in question, for example a bridge, is studied by coupling a small number of physical components with a numerical model of the rest of the structure. Undoubtedly, the success of such a hybrid approach, especially for dynamic real-time applications, hinges on effective integration of the cyber and physical components of the system. This project provides the essential building blocks and a computational integration platform to enable real-time hybrid testing of civil engineering structures. Design and development of physical components, multi-level numerical models, and real-time control algorithms will be conducted at Purdue University. Washington University will provide an adaptive, configurable concurrency platform and communication mechanisms that meet the strict scheduling constraints of real-time cyber-physical systems. The two institutions will collaboratively design a prototype system and conduct extensive testing to validate the integration of the various components and evaluate system performance. Specifications, software, benchmarks, and data developed during the course of this project will be made freely available to the cyber-physical research community. In addition to directly advancing the state-of-the-art in real-time hybrid testing, this research will also impact the areas of avionics, automotive design, smart grids for distributed power transmission and similar applications in other domains.

This award supports the first Summer School on Cyber-Physical Systems, held at the Georgia Institute of Technology, Atlanta, Georgia, June 22-25, 2009. NSF funds support outreach and enable the participation of US graduate students and early career faculty in this international event. Cyber Physical Systems (CPS) are systems that rely on a tight integration of computation, communication, and controls, for their operation and interaction with the physical environment in which they are deployed. Such systems must be able to operate safely, dependably, securely, efficiently and in real-time, in potentially highly uncertain or unstructured environments. CPS are expected to have great technical, economic and societal impacts in the near future. The objective of the Georgia Tech Summer School on Cyber-Physical Systems is to establish a forum for intellectual exchange on CPS science and technology for researchers from industry and academia. The format of the Summer School is a five-day meeting, organized around the different aspects of Cyber Physical Systems. The topical areas covered include: formal methods, distributed embedded systems, networked control systems, embedded software, scheduling, platforms, and applications.

The focus of this project is the efficient implementation of multiple control and non-control automotive applications in a distributed embedded system (DES) with a goal of developing safe, dependable, and secure Automotive CPS. DES are highly attractive due to the fact that they radically enhance the capabilities of the underlying system by linking a range of devices and sensors and allowing information to be processed in unprecedented ways. Deploying control and non-control applications on a modern DES, which uses advanced processor and communication technology, introduces a host of challenges in their analysis and synthesis, and leads to a large semantic gap between models and their implementation. This gap will be filled via the development of a novel CPS architecture by stitching together common fundamental principles of multimodality from real-time systems and related notions of switching in control theory and integrating them into a co-design of real-time platforms and adaptive controllers. This architecture will be validated at the Toyota Technical Center in the context of engine control and diagnostics. The results of this project will provide the science and technology for a foundation in any and all infrastructure systems ranging from finance and energy to telecommunication and transportation where distributed embedded systems are present. In addition to training the graduate and undergraduate students, and mentoring a post-doctoral associate who will gain multi-domain expertise in advanced control, real-time computation and communication, and performance analysis, an inter-school graduate and an integrated summer course will be developed on control in embedded systems and combined with on-going outreach programs at MIT and UPenn for minority and women undergraduate students and K-12 students.

This project develops a framework for design automation of cyber-physical systems to augment human interaction with complex systems that integrate across computational and physical environments. As a design driver, the project develops a Body/Brain Computer Interface (BBCI) for the population of functionally locked-in individuals, who are unable to interact with the physical world through movement and speech. The BBCI will enable communication with other humans through expressive language generation and interaction with the environment through robotic manipulators. Utilizing advances in system-level design, this project develops a holistic framework for design and implementation of heterogeneous human-in-the-loop cyber-physical systems composed of physically distributed, networked components. It will advance BBCI technology by incorporating context aware inference and learning of task-specific human intent estimation in applications involving semi-autonomous robotic actuators and an efficient wireless communication framework. The results of this project are expected to significantly speed up the design of complex cyber-physical systems. By accelerating the path from idea to prototype, this work shortens the time frame of and cost of development for assistive technology to improve the quality-of-life for functionally locked-in individuals. This project establishes an open prototyping platform and a design framework for rapid exploration of other novel human-in-the-loop applications. The open platform will foster undergraduate involvement in cyber-physical systems research, building confidence and expertise. In addition, new activities at the Museum of Science in Boston will engage visitors to experiment with systematic design principles in context of a brain computer interface application, while offering learning opportunities about basic brain functions.

This project aims to develop a computational framework and a physical platform for enabling dense networks of micro-robotic swarms for medical applications. The approach relies on a new stochastic framework for design and analysis of dense networks, as well as new fabrication and characterization methods for building and understanding bacteria propelled micro-robotic swarms. This project enhances the CPS science beyond passive networks of millimeter-scale bio-implantable devices with active networks of micro-robotic swarms that could be more effective in combating various critical diseases with minimal impact on the human body. Three major research objectives are proposed in this project: 1) Statistical physics inspired approach to the modeling and analysis of dense networks of swarms: The theory envisioned for characterizing the dynamics of dense networks of swarms aims at achieving ?beyond Turing? computation via dense networks, designing autonomous reliable communication protocols for dense networks, and estimating and controlling their performance; 2) Fabrication and steering of swarms of bacteria propelled swimming micro-robots: Large numbers of both chemotactic and magnetotactic bacteria integrated micro-robotic bodies will be fabricated using self-assembly and micro/nano-fabrication methods. Chemotaxis and magnetotaxis will be respectively used as passive and active steering mechanisms for navigating the swarms of micro-robots in small spaces to perform specified tasks; 3) Characterization of the behavior and control of bacteria propelled micro-robotic swarms: To validate and fine tune the proposed computational models, the motion and behavior of single and large numbers of bacteria propelled micro-robots will be characterized using optical and other microscopy methods. Intellectual Merit: The research breakthrough proposed herein consists of building a new physical platform for micro-robotic swarms by using attached bacteria as on-board actuators and chemotaxis and magnetotaxis as passive and active steering control methods, and developing a new computational dense network framework for designing and analyzing such stochastic micro-robotic swarms. The statistical computational framework to be developed in this study will improve understanding of swarming behavior and control of large numbers of bacteria propelled micro-robots. This framework offers an integrated approach towards CPS design that is meant to operate under uncertainty conditions, yet be able to succeed in performing a specified task through self-organization and collective behavior. This bottom-top approach is meant to improve the theoretical foundations of the current computational models of CPS. Broader Impacts: The resulting computational framework and the physical platform could be adapted to a wide range of different stochastic dense network systems ranging from migration of cancer cell populations or dynamics of virus populations to immune system support and modeling. The proposed swarms of bacteria integrated micro-robots have potential future applications in health-care for the diagnosis of diseases and targeted drug delivery inside the stagnant or low velocity fluids of the human body or the medical diagnosis inside lab-on-a-chip microfluidic devices. Such health-care applications could improve the welfare of our society. To foster learning and training of next generation CPS workforce, the PIs plan to emphasize a cross-disciplinary approach to teaching topics that are usually offered in disjoint tracks. The PIs will integrate the CPS research activities in this study into their newly developed courses, and they will also teach one of these courses jointly. As a joint international educational activity, a three-day Summer School will be held alternately in US and Europe every year on various CPS topics related to our project. This will help building a strong international CPS community and training US and European students in CPS topics. The PIs will present the research results of this project to children, K-12 students, K-12 teachers, IEEE and ACM student members, and college students inside and outside of USA through public lectures. This project and the Sloan Foundation will support underrepresented and minority graduate students in the project. Moreover, underrepresented minority undergraduate students will be trained through the CMU ICES summer outreach program called The SURE Thing and the NSF REU program.

This project integrates digital microfluidics with thin-film photodetectors and control software to realize DNA target sensing using fluorescence. This cyberphysical vision is being realized through tight coupling between physical components, the microfluidic platform and miniaturized sensors, and cyber components, software for control, decision-making, and adaptation. Such a level of integration, decision, and controlled reconfigurability is a significant step forward in clinical diagnostics using digital microfluidic biochips. Topics being investigated include: (i) silicon-based digital microfluidics and integration of optical sensors; (ii) closed-loop operation and run-time optimization under software control; (iii) decision-tree architectures, adaptive reconfiguration, and error recovery. A complete testbed is being developed for nucleic acid identification on a fabricated chip with detection sites. Cyberphysical system integration will transform biochip use, in the same way as compilers and operating systems revolutionized computing, and design automation revolutionized chip design. Benefits to society include the potential to transform personalized medicine, home diagnostics, and portable diagnostics. Integration of digital microfluidics, optical sensing, and software control has the potential to create systems that can be used by any person, regardless of sample preparation skill. One example is the identification of bacterial DNA associated with bacterial blood infection (sepsis), which results in death if not diagnosed early (this is in the top 10 causes of death in the US). Students are being trained through a Senior Design course to understand the design

In many important situations, analytically predicting the behavior of physical systems is not possible. For example, the three dimensional nature of physical systems makes it provably impossible to express closed-form analytical solutions for even the simplest systems. This has made experimentation the primary modality for designing new cyber-physical systems (CPS). Since physical prototyping and experiments are typically costly and hard to conduct, "virtual experiments" in the form of modeling and simulation can dramatically accelerate innovation in CPS. Unfortunately, major technical challenges often impede the effectiveness of modeling and simulation. This project develops foundations and tools for overcoming these challenges. The project focuses on robotics as an important, archetypical class of CPS, and consists of four key tasks: 1) Compiling and analyzing a benchmark suite for modeling and simulating robots, 2) Developing a meta-theory for relating cyber-physical models, as well as tools and a test bed for robot modeling and simulation, 3) Validating the research results of the project using two state-of-the-art robot platforms that incorporate novel control technologies and will require novel programming techniques to fully realize their potential 4) Developing course materials incorporating the project's research results and test bed. With the aim of accelerating innovation in a wide range of domains including stroke rehabilitation and prosthetic limbs, the project is developing new control concepts and modeling and simulation technologies for robotics. In addition to new mathematical foundations, models, and validation methods, the project will also develop software tools and systematic methods for using them. The project trains four doctoral students; develops a new course on modeling and simulation for cyber-physical systems that balances both control and programming concepts; and includes an outreach component to the public and to minority-serving K-12 programs.