The objective of this research is to develop a cyber-physical system capable of displaying the in vivo surgical area directly onto patients' skin in real-time high definition. This system will give surgeons an x-ray vision experience, since they see directly through the skin, and remove a spatial bottleneck and additional scarring caused by laparoscopes in minimally invasive surgery. The approach is to develop micro-cameras that: occupy no space required by surgical tools, produce no additional scarring to the patient, and transfer wireless high-definition video images. A virtual view generating system will project the panoramic videos from all cameras to the right spot on the patient?s body with geometry and color distortion compensation. A surgeon-camera-interaction system will be investigated to allow surgeons to control viewpoint with gesture recognition and finger tracking. Novel techniques will be developed for zero-latency high-definition wireless video transfer through the in vivo/ex vivo medium. Image viewpoint alignment and distortion compensation in real time will also be investigated. The results will be a potential paradigm shift in minimally invasive surgery. The proposed work benefits the millions of surgeries capable of being performed through a single incision in the abdomen by providing virtually transparent skin to surgeons who will enjoy all the visual benefits of open-cavity surgery without all the associated risks to the patient. The goals of this research are extremely hands-on and immediately applicable to outreach activities that can excite youth, minority students, and others about the science, medicine a and engineering careers.

The objective of this research is to establish a foundational framework for smart grids that enables significant penetration of renewable DERs and facilitates flexible deployments of plug-and-play applications, similar to the way users connect to the Internet. The approach is to view the overall grid management as an adaptive optimizer to iteratively solve a system-wide optimization problem, where networked sensing, control and verification carry out distributed computation tasks to achieve reliability at all levels, particularly component-level, system-level, and application level. Intellectual merit. Under the common theme of reliability guarantees, distributed monitoring and inference algorithms will be developed to perform fault diagnosis and operate resiliently against all hazards. To attain high reliability, a trustworthy middleware will be used to shield the grid system design from the complexities of the underlying software world while providing services to grid applications through message passing and transactions. Further, selective load/generation control using Automatic Generation Control, based on multi-scale state estimation for energy supply and demand, will be carried out to guarantee that the load and generation in the system remain balanced. Broader impact. The envisioned architecture of the smart grid is an outstanding example of the CPS technology. Built on this critical application study, this collaborative effort will pursue a CPS architecture that enables embedding intelligent computation, communication and control mechanisms into physical systems with active and reconfigurable components. Close collaborations between this team and major EMS and SCADA vendors will pave the path for technology transfer via proof-of-concept demonstrations.

The objective of this research is to develop an intuitive user interface for functional electrical stimulation (FES), which uses surgically-implanted electrodes to stimulate muscles in spinal cord-injured (SCI) patients. The challenge is to enable high-level tetraplegic patients to regain the use of their own arm. The approach is to develop a multi-modal Bayesian user-intent decoder; use natural muscle synergies to generate appropriate low-dimensional muscle activation signals in a feedforward controller; develop a feedback controller to enhance the performance of the feedforward controller; and test the system with SCI patients on daily living tasks, such as reaching, grasping, and eating. The challenge problem of restoring arm use to SCI patients will lead to new design principles for cyber-physical systems interfacing neural and biological systems with engineered computation and electrical power systems. The tight integration of the proposed user interface and controller with the users own control system requires a deep understanding of biological design principles such as nested feedback loops at different time and length scales, noisy signals, parallel processing, and highly coupled neuromechanical systems. This work will lead to new technology that dramatically improves the lives of spinal cord-injured patients. These patients often have no cognitive impairment and have long life spans after injury. The goal is to enable these patients to eat, reach, and grasp nearby objects. These tasks are critical for independent living and quality of life. This work will also help train a new generation of students in human-machine interfaces at the undergraduate, graduate, and postdoctoral levels.

The objective of this research is to investigate and implement a software architecture to improve productivity in the development of rapidly deployable, robust, real-time situational awareness and response applications. The approach is based on a modular cross-layered architecture that combines a data-centric descriptive programming model with an overlay-based communication model. The cross-layer architecture will promote an efficient implementation. Simultaneously, the data-centric programming model and overlay-based communication model will promote a robust implementation that can take advantage of heterogeneous resources and respond to different failures. There is currently no high-level software architecture that meets the stringent requirements of many situational awareness and response applications. The proposed project will fill this void by developing a novel data-centric programming model that spans devices with varying computational and communication capabilities. Similarly, the overlay communication model will extend existing work by integrating network resources with the programming model. This cross-layer design will promote the implementation of efficient and robust applications. This research will benefit society by providing emergency responders with software tools that present key information in a timely fashion. This, in turn, will increase safety and reduce economic and human loss during emergencies. The productivity gains in deploying sensors and mobile devices will benefit other domains, such as field research using sensor networks. Software will be released under an open-source license to promote the use by government agencies, research institutions, and individuals. Products of this research, including the software, will be used in courses at the University of North Carolina.

The objective of this research is to develop principles and tools for the design of control systems using highly distributed, but slow, computational elements. The approach of this research is to build an architecture that uses highly parallelized, simple computational elements incorporating nonlinearities, time delay and asynchronous computation as integral design elements. Tools for the design of non-deterministic protocols will be developed and demonstrated using an existing multi-vehicle testbed at Caltech. The motivation for using "slow computing" is to develop new feedback control architectures for applications where computational power is extremely limited. Examples of such systems are those where the energy usage of the system must remain small, either due to the source of power available (e.g. batteries or solar cells) or the physical size of the device (e.g. microscale and nanoscale robots). A longer term application area is in the design of control systems using novel computing substrates, such as biological circuits. A critical element in both cases is the tight coupling between the dynamics of the underlying process and the temporal properties of the algorithm that is controlling it. The implementation plan for this project involves students from multiple disciplines (including bioengineering, computer science, electrical engineering and mechanical engineering) as well as at multiple experience levels (sophomores through PhD students) working together on a set of interlinked research problems. The project is centered in the Control and Dynamical Systems department at Caltech, which has a strong record of recruiting women and underrepresented minority students into its programs.

The objective of this research is to develop the scientific foundation for the quantitative analysis and design of control networks. Control networks are wireless substrates for industrial automation control, such as the WirelessHART and Honeywell's OneWireless, and have fundamental differences over their sensor network counterparts as they also include actuation and the physical dynamics. The approach of the project focuses on understanding cross-cutting interfaces between computing systems, control systems, sensor networks, and wireless communications using time-triggered architectures. The intellectual merit of this research is based on using time-triggered communication and computation as a unifying abstraction for understanding control networks. Time-triggered architectures enable the natural integration of communication, computation, and physical aspects of control networks as switched control systems. The time-triggered abstraction will serve for addressing the following interrelated themes: Optimal Schedules via Quantitative Automata, Quantitative Analysis and Design of Control Networks: Wireless Protocols for Optimal Control: Quantitative Trust Management for Control Networks. Various components of this research will be integrated into the PIs' RAVEN control network which is compatible with both WirelessHART and OneWireless specifications. This provides a direct path for this proposal to have immediate industrial impact. In order to increase the broader impact of this project, this project will launch the creation of a Masters' program in Embedded Systems, one of the first in the nation. The principle that guides the curriculum development of this novel program is a unified systems view of computing, communication, and control systems.

This proposed CPS project aims to enable intelligent telesurgery in which a surgeon, or a distributed team of surgeons, can work on tiny regions in the body with minimal access. The University of Washington will expand an existing open surgical robot testbed, and create a robust infrastructure for cyber-physical systems with which to extend traditional real-time control and teleoperation concepts by adding three new interfaces to the system: networking, intelligent robotics, and novel non-linear controllers. Intellectual Merit: This project aims to break new ground beyond teleoperation by adding advanced robotic functions. Equally robust and flexible networking, high-level interfaces, and novel controllers will be added to the existing sytsem. The resulting system will be an open architecture and a substrate upon which many cyber-physical system ideas and algorithms will be tested under realistic conditions. The platforms proven physical robustness will permit rigorous evaluation of results and the open interfaces will encourage collaboration and sharing of results. Broader Impacts: We expect the results to enable new research in multiple ways. First, the collaborators such as Johns Hopkins, U.C. Santa Cruz, and several foreign institutions will be able to remotely connect to new high level interfaces provided by this project. Second, for the first time a robust and completely open surgical telerobot will be available for research so that CPS researchers do not need to be limited to isolated toy problems but instead be able to prototype advanced surgical robotics techniques and evaluate them in realistic contexts including animal procedures.

The objective of this research is the development of novel control architectures and computationally efficient controller design algorithms for distributed cyber-physical systems with decentralized information infrastructures and limited communication capabilities. Active safety in Intelligent Transportation Systems will be the focus cyber-physical application. For the successful development and deployment of cooperative active safety systems, it is critical to develop theory and techniques to design algorithms with guaranteed safety properties and predictable behavior. The approach is to develop a new methodology for the design of communicating distributed hybrid controllers by integrating in a novel manner discrete-event controller design and hybrid controller design and optimization. The methodology to be developed will exploit problem decomposition and will have significant technological impact for a large class of cyber-physical systems that share features of modularity in system representation, partial information, and limited communication. The focus on distributed control strategies with limited communication among agents is addressing an important gap in existing control theories for cyber-physical systems. The approach will mitigate the computational limitations of existing approaches to control design for hybrid systems. Given the focus on cooperative active safety in Intelligent Transportation Systems, the results of this effort will have significant societal impact in terms of increased traffic safety and reduced number and severity of accidents. The broader impacts of this proposal also include involvement of high-school and undergraduate students and curriculum development by incorporating results of research into existing courses on cyber-physical systems.